Advances in modeling cellular state dynamics: integrating omics data and predictive techniques
Dynamic modeling of cellular states has emerged as a pivotal approach for understanding complex biological processes such as cell differentiation, disease progression, and tissue development. This review provides a comprehensive overview of current approaches for modeling cellular state dynamics, fo...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Animal Cells and Systems |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19768354.2024.2449518 |
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| _version_ | 1841546879674875904 |
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| author | Sungwon Jung |
| author_facet | Sungwon Jung |
| author_sort | Sungwon Jung |
| collection | DOAJ |
| description | Dynamic modeling of cellular states has emerged as a pivotal approach for understanding complex biological processes such as cell differentiation, disease progression, and tissue development. This review provides a comprehensive overview of current approaches for modeling cellular state dynamics, focusing on techniques ranging from dynamic or static biomolecular network models to deep learning models. We highlight how these approaches integrated with various omics data such as transcriptomics, and single-cell RNA sequencing could be used to capture and predict cellular behavior and transitions. We also discuss applications of these modeling approaches in predicting gene knockout effects, designing targeted interventions, and simulating organ development. This review emphasizes the importance of selecting appropriate modeling strategies based on scalability and resolution requirements, which vary according to the complexity and size of biological systems under study. By evaluating strengths, limitations, and recent advancements of these methodologies, we aim to guide future research in developing more robust and interpretable models for understanding and manipulating cellular state dynamics in various biological contexts, ultimately advancing therapeutic strategies and precision medicine. |
| format | Article |
| id | doaj-art-2deb1a04f6e5410da2eab358523b158d |
| institution | Kabale University |
| issn | 1976-8354 2151-2485 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj-art-2deb1a04f6e5410da2eab358523b158d2025-01-10T15:27:57ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852025-12-01291728310.1080/19768354.2024.2449518Advances in modeling cellular state dynamics: integrating omics data and predictive techniquesSungwon Jung0Department of Genome Medicine and Science, Gachon University College of Medicine, Incheon, Republic of KoreaDynamic modeling of cellular states has emerged as a pivotal approach for understanding complex biological processes such as cell differentiation, disease progression, and tissue development. This review provides a comprehensive overview of current approaches for modeling cellular state dynamics, focusing on techniques ranging from dynamic or static biomolecular network models to deep learning models. We highlight how these approaches integrated with various omics data such as transcriptomics, and single-cell RNA sequencing could be used to capture and predict cellular behavior and transitions. We also discuss applications of these modeling approaches in predicting gene knockout effects, designing targeted interventions, and simulating organ development. This review emphasizes the importance of selecting appropriate modeling strategies based on scalability and resolution requirements, which vary according to the complexity and size of biological systems under study. By evaluating strengths, limitations, and recent advancements of these methodologies, we aim to guide future research in developing more robust and interpretable models for understanding and manipulating cellular state dynamics in various biological contexts, ultimately advancing therapeutic strategies and precision medicine.https://www.tandfonline.com/doi/10.1080/19768354.2024.2449518Cellular state dynamicscell phenotype modelingdisease progression modelingcellular reprogramming |
| spellingShingle | Sungwon Jung Advances in modeling cellular state dynamics: integrating omics data and predictive techniques Animal Cells and Systems Cellular state dynamics cell phenotype modeling disease progression modeling cellular reprogramming |
| title | Advances in modeling cellular state dynamics: integrating omics data and predictive techniques |
| title_full | Advances in modeling cellular state dynamics: integrating omics data and predictive techniques |
| title_fullStr | Advances in modeling cellular state dynamics: integrating omics data and predictive techniques |
| title_full_unstemmed | Advances in modeling cellular state dynamics: integrating omics data and predictive techniques |
| title_short | Advances in modeling cellular state dynamics: integrating omics data and predictive techniques |
| title_sort | advances in modeling cellular state dynamics integrating omics data and predictive techniques |
| topic | Cellular state dynamics cell phenotype modeling disease progression modeling cellular reprogramming |
| url | https://www.tandfonline.com/doi/10.1080/19768354.2024.2449518 |
| work_keys_str_mv | AT sungwonjung advancesinmodelingcellularstatedynamicsintegratingomicsdataandpredictivetechniques |