Thyrotropin reference interval in older adults
It is estimated that by the year 2050, 16% of the world’s population will be 65 years old and above. As the global aging population continues to grow, there is an increasing focus on thyroid disorders among older individuals. Thyrotropin is widely used in diagnosing subclinical thyroid diseases due...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2025-01-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/14/2/EC-24-0435.xml |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841555884918964224 |
|---|---|
| author | Xiaodan Zhai Yongze Li Xiaochun Teng Weiping Teng Xiaoguang Shi Zhongyan Shan |
| author_facet | Xiaodan Zhai Yongze Li Xiaochun Teng Weiping Teng Xiaoguang Shi Zhongyan Shan |
| author_sort | Xiaodan Zhai |
| collection | DOAJ |
| description | It is estimated that by the year 2050, 16% of the world’s population will be 65 years old and above. As the global aging population continues to grow, there is an increasing focus on thyroid disorders among older individuals. Thyrotropin is widely used in diagnosing subclinical thyroid diseases due to its high sensitivity as an indicator of changes in thyroid function. However, thyrotropin levels change with age, and different reference intervals have been proposed in various studies. The variation in thyrotropin ranges among older adults is probably caused by the heterogeneity of the studied population. This review aims to provide an overview of the existing literature on thyrotropin reference intervals in older adults and their distinction as adaptive or pathologic. Recent research indicates that older individuals may have slightly elevated levels of thyrotropin and higher upper limits of reference intervals. Therefore, a higher thyrotropin threshold for diagnosing and treating subclinical hypothyroidism in the elderly seems reasonable. |
| format | Article |
| id | doaj-art-2dab5c4cf5f94c6c9e8a945838c1ed6c |
| institution | Kabale University |
| issn | 2049-3614 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj-art-2dab5c4cf5f94c6c9e8a945838c1ed6c2025-01-07T17:17:12ZengBioscientificaEndocrine Connections2049-36142025-01-0114210.1530/EC-24-04351Thyrotropin reference interval in older adultsXiaodan Zhai0Yongze Li1Xiaochun Teng2Weiping Teng3Xiaoguang Shi4Zhongyan Shan5Department of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, P. R. ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, P. R. ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, P. R. ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, P. R. ChinaDepartment of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P. R. ChinaDepartment of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, P. R. ChinaIt is estimated that by the year 2050, 16% of the world’s population will be 65 years old and above. As the global aging population continues to grow, there is an increasing focus on thyroid disorders among older individuals. Thyrotropin is widely used in diagnosing subclinical thyroid diseases due to its high sensitivity as an indicator of changes in thyroid function. However, thyrotropin levels change with age, and different reference intervals have been proposed in various studies. The variation in thyrotropin ranges among older adults is probably caused by the heterogeneity of the studied population. This review aims to provide an overview of the existing literature on thyrotropin reference intervals in older adults and their distinction as adaptive or pathologic. Recent research indicates that older individuals may have slightly elevated levels of thyrotropin and higher upper limits of reference intervals. Therefore, a higher thyrotropin threshold for diagnosing and treating subclinical hypothyroidism in the elderly seems reasonable.https://ec.bioscientifica.com/view/journals/ec/14/2/EC-24-0435.xmlthyrotropinreference intervalolder adultshypothyroidism |
| spellingShingle | Xiaodan Zhai Yongze Li Xiaochun Teng Weiping Teng Xiaoguang Shi Zhongyan Shan Thyrotropin reference interval in older adults Endocrine Connections thyrotropin reference interval older adults hypothyroidism |
| title | Thyrotropin reference interval in older adults |
| title_full | Thyrotropin reference interval in older adults |
| title_fullStr | Thyrotropin reference interval in older adults |
| title_full_unstemmed | Thyrotropin reference interval in older adults |
| title_short | Thyrotropin reference interval in older adults |
| title_sort | thyrotropin reference interval in older adults |
| topic | thyrotropin reference interval older adults hypothyroidism |
| url | https://ec.bioscientifica.com/view/journals/ec/14/2/EC-24-0435.xml |
| work_keys_str_mv | AT xiaodanzhai thyrotropinreferenceintervalinolderadults AT yongzeli thyrotropinreferenceintervalinolderadults AT xiaochunteng thyrotropinreferenceintervalinolderadults AT weipingteng thyrotropinreferenceintervalinolderadults AT xiaoguangshi thyrotropinreferenceintervalinolderadults AT zhongyanshan thyrotropinreferenceintervalinolderadults |