Targeted inhibition of gastric cancer progression via a chitosan-RNU11 siRNA nanoparticle delivery system: mechanistic insights and therapeutic potential

Targeted inhibition of gastric cancer progression via a chitosan-RNU11 siRNA nanoparticle delivery system: mechanistic insights and therapeutic potential

Abstract Background Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide. The prognosis for advanced GC is poor, necessitating innovative therapeutic strategies. Small interfering RNA (siRNA) offers a promising avenue for gene-specific cancer treatment. However, effectiv...

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Bibliographic Details
Main Authors: Peng Cheng, Zhengrong Zhong, Yanling Wang, Caituan Feng, Jitong Zheng, SuogaoWang, Xiangjun Meng, Dong Wang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cancer Nanotechnology
Subjects:
Gastric cancer
Chitosan nanoparticles
RNU11
Si-RNU11
Wnt pathway
Therapeutic target
Online Access:https://doi.org/10.1186/s12645-025-00311-8
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