Follistatin‐like 1 promotes cardiac fibroblast activation and protects the heart from rupture

Follistatin‐like 1 promotes cardiac fibroblast activation and protects the heart from rupture

Abstract Follistatin‐like 1 (Fstl1) is a secreted protein that is acutely induced in heart following myocardial infarction (MI). In this study, we investigated cell type‐specific regulation of Fstl1 and its function in a murine model of MI. Fstl1 was robustly expressed in fibroblasts and myofibrobla...

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Bibliographic Details
Main Authors: Sonomi Maruyama, Kazuto Nakamura, Kyriakos N Papanicolaou, Soichi Sano, Ippei Shimizu, Yasuhide Asaumi, Maurice J van den Hoff, Noriyuki Ouchi, Fabio A Recchia, Kenneth Walsh
Format: Article
Language:English
Published: Springer Nature 2016-05-01
Series:EMBO Molecular Medicine
Subjects:
cardiokine
fibrosis
infarct healing
myocardial infarction
Online Access:https://doi.org/10.15252/emmm.201506151
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https://doi.org/10.15252/emmm.201506151

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