Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community
Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, characterized by an inflammatory process. Gut mycobiota community dysbiosis has been reported that is closely related to the development of IBD. Our previous findings indicated that poly...
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Tsinghua University Press
2024-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2023.9250019 |
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| author | Shuiling He Ruipeng Yang Jiangying Shi Ning An Shuhua Shan Zhuoyu Li Xiushan Dong |
| author_facet | Shuiling He Ruipeng Yang Jiangying Shi Ning An Shuhua Shan Zhuoyu Li Xiushan Dong |
| author_sort | Shuiling He |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, characterized by an inflammatory process. Gut mycobiota community dysbiosis has been reported that is closely related to the development of IBD. Our previous findings indicated that polyphenol of the inner shell (BPIS) from foxtail millet bran could restore the gut microbiome and inhibit the progress of colorectal cancer (CRC). In the present study, we studied the anti-inflammatory potential of BPIS in the dextran sodium sulfate (DSS)-induced mouse colitis model. Data suggested that BPIS alleviated experimental colitis by restoring body weight, colonic length and protecting the epithelial architecture from damage by DSS. Moreover, we found that BPIS strengthened the gut barrier function and inhibited the activation of Wnt1/β-catenin pathway. Gene sequence analysis indicated that BPIS remodeled the overall structure of the gut mycobiota from colitis mice toward that of the normal counterparts, including 1 phylum and 9 genera. Interestingly, BPIS significantly increased the abundance of Aspergillus ruber. It further verified that BPIS significantly promoted the growth of A. ruber in vitro. Collectively, BPIS has great potential to develop into an effective against IBD drug. |
| format | Article |
| id | doaj-art-2cdf069536b34f80b1591b70c5dcadf6 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-2cdf069536b34f80b1591b70c5dcadf62025-01-10T06:57:02ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363339335010.26599/FSHW.2023.9250019Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal communityShuiling He0Ruipeng Yang1Jiangying Shi2Ning An3Shuhua Shan4Zhuoyu Li5Xiushan Dong6Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, ChinaInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, ChinaInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, ChinaInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, ChinaInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, ChinaInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, ChinaGeneral Surgery Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospitalof Shanxi Medical University, Taiyuan 030032, ChinaInflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, characterized by an inflammatory process. Gut mycobiota community dysbiosis has been reported that is closely related to the development of IBD. Our previous findings indicated that polyphenol of the inner shell (BPIS) from foxtail millet bran could restore the gut microbiome and inhibit the progress of colorectal cancer (CRC). In the present study, we studied the anti-inflammatory potential of BPIS in the dextran sodium sulfate (DSS)-induced mouse colitis model. Data suggested that BPIS alleviated experimental colitis by restoring body weight, colonic length and protecting the epithelial architecture from damage by DSS. Moreover, we found that BPIS strengthened the gut barrier function and inhibited the activation of Wnt1/β-catenin pathway. Gene sequence analysis indicated that BPIS remodeled the overall structure of the gut mycobiota from colitis mice toward that of the normal counterparts, including 1 phylum and 9 genera. Interestingly, BPIS significantly increased the abundance of Aspergillus ruber. It further verified that BPIS significantly promoted the growth of A. ruber in vitro. Collectively, BPIS has great potential to develop into an effective against IBD drug.https://www.sciopen.com/article/10.26599/FSHW.2023.9250019foxtail millet braninflammatory bowel diseasegut barrierwnt1/β-cateninfungal communityaspergillus ruber |
| spellingShingle | Shuiling He Ruipeng Yang Jiangying Shi Ning An Shuhua Shan Zhuoyu Li Xiushan Dong Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community Food Science and Human Wellness foxtail millet bran inflammatory bowel disease gut barrier wnt1/β-catenin fungal community aspergillus ruber |
| title | Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community |
| title_full | Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community |
| title_fullStr | Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community |
| title_full_unstemmed | Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community |
| title_short | Polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community |
| title_sort | polyphenol from foxtail millet bran alleviates experimental colitis in mice by remodulating intestinal fungal community |
| topic | foxtail millet bran inflammatory bowel disease gut barrier wnt1/β-catenin fungal community aspergillus ruber |
| url | https://www.sciopen.com/article/10.26599/FSHW.2023.9250019 |
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