Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

N -Acetylneuraminic acid (Neu5Ac) is a negatively charged nine-carbon amino sugar that is often the peripheral sugar in human cell-surface glycoconjugates. Some bacteria scavenge, import, and metabolize Neu5Ac or redeploy it on their cell surfaces for immune evasion. The import of Neu5Ac by many bac...

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Bibliographic Details
Main Authors: Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
TRAP transporter
Neu5Ac binding
Sodium ion
sialic acid transport
Fusobacterium
cryo-EM
Online Access:https://elifesciences.org/articles/98158
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