A novel metal‐organic framework encapsulated iridium oxide nanozyme enhanced antisense oligonucleotide combo for osteoarthritis synergistic therapy

A novel metal‐organic framework encapsulated iridium oxide nanozyme enhanced antisense oligonucleotide combo for osteoarthritis synergistic therapy

Abstract Osteoarthritis (OA) is associated with metabolic imbalance of articular cartilage and an increase of intracellular reactive oxygen species (ROS). Synergistic therapy based on the codelivery of ROS scavengers and antisense oligonucleotides (ASO) into chondrocytes has the potential to effecti...

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Bibliographic Details
Main Authors: Shuqi Wu, Fang Nan, Kewen Zhang, Wan Hao, Di Shi, Yang Li, Wei Deng, Nur Jarhen, Kaixuan Li, Yunyun Xiao, Jun Li, Xiao Lin
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Aggregate
Subjects:
antisense oligonucleotides
cartilage metabolism
drug delivery
IrO2 nanozyme
osteoarthritis treatment
reactive oxygen species scavenging
Online Access:https://doi.org/10.1002/agt2.635
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https://doi.org/10.1002/agt2.635

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