GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restriction

GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restriction

Abstract Background Gestational diabetes mellitus (GDM) has been associated with several fetal complications, such as macrosomia and fetal growth restriction (FGR). Infants from GDM associated FGR are at increased risk for adult-onset obesity and associated metabolic disorders. However, the underlyi...

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Main Authors: Qin Zhang, Xi Yuan, Xiaojin Luan, Ting Lei, Yiran Li, Wei Chu, Qi Yao, Philip N. Baker, Hongbo Qi, Hui Li
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
GLUT1
Ferroptosis
Gestational diabetes mellitus
Fetal growth restriction
AMPK/ACC pathway
Online Access:https://doi.org/10.1186/s10020-024-01028-x
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https://doi.org/10.1186/s10020-024-01028-x

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