Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction

Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction

Abstract Myocardial fibrosis leads to cardiac dysfunction and arrhythmias in heart failure with preserved ejection fraction (HFpEF), but the underlying mechanisms remain poorly understood. Here, RNA sequencing identifies Forkhead Box1 (FoxO1) signaling as abnormal in male HFpEF hearts. Genetic suppr...

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Main Authors: Thassio Mesquita, Rodrigo Miguel-dos-Santos, Weixin Liu, Mario Fournier, Russell G. Rogers, Jocelyn Alfaro, Asma Nawaz, Lizbeth Sanchez, Xaviar M. Jones, Liang Li, Eduardo Marbán, Eugenio Cingolani
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56186-1
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