High levels of a comprehensive set of matrix metalloproteinases in endometriotic lesions: validating the key role of cellular senescence in endometriosis pathogenesis

High levels of a comprehensive set of matrix metalloproteinases in endometriotic lesions: validating the key role of cellular senescence in endometriosis pathogenesis

ABSTRACT Objective: To investigate the roles of cellular senescence and dysfunctional extracellular matrix metalloproteinases (MMPs) in perpetuating chronic inflammation and facilitating the establishment of endometriotic lesions. By analyzing the MMP activity in the endometrial tissue and peritone...

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Bibliographic Details
Main Authors: Laura Palmieri, Helena Malvezzi, Bruna Cestari de Azevedo, Eduardo Varejão Díaz Placencia, Eliane Antonioli, Sérgio Podgaec
Format: Article
Language:English
Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2025-08-01
Series:Einstein (São Paulo)
Subjects:
Endometriosis
Cellular senescence
Inflammation
Extracellular matrix
Metalloproteinases
Senescence-associated secretory phenotype
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082025000100245&lng=en&tlng=en
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