Manual Segmentation of 12 Layers of the Retina and Choroid through SD-OCT in Intermediate AMD: Repeatability and Reproducibility
Abstract Purpose: To evaluate the repeatability and reproducibility of the segmentation of 12 layers of the retina and the choroid, performed manually by SD-OCT, along the horizontal meridian at three different temporal moments, and to evaluate its concordance with the same measurements performed by...
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Knowledge E
2021-07-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | https://doi.org/10.18502/jovr.v16i3.9435 |
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| author | Pedro Camacho Marco Dutra-Medeiros Luís Salgueiro Sílvia Sadio Paulo C. Rosa |
| author_facet | Pedro Camacho Marco Dutra-Medeiros Luís Salgueiro Sílvia Sadio Paulo C. Rosa |
| author_sort | Pedro Camacho |
| collection | DOAJ |
| description | Abstract Purpose: To evaluate the repeatability and reproducibility of the segmentation of 12 layers of the retina and the choroid, performed manually by SD-OCT, along the horizontal meridian at three different temporal moments, and to evaluate its concordance with the same measurements performed by two other operators in intermediate AMD. Methods: A cross-sectional study of 40 eyes from 40 subjects with intermediate AMD was conducted. The segmentation was performed manually, using SD-OCT. The 169 measurements per eye were repeated at three time points to study the intra-operator variability. The same process was repeated a single time by two different trained operators for the inter-operator variability. Results: Forty participants (28 women and 12 men) were enrolled in this study, with an average age of 76.4 ± 8.2 (range, 55–92 years). Overall, the maximum values of the various structures were found in the 3 mm of the macula. Intra-operator variability: the highest ICC values turned out to be discovered in thicker locations. Inter-operator variability: except correlation values of 0.826 (0.727; 0.898) obtained in the OPL (T2.5) and 0.634 (0.469; 0.771) obtained in the IPL (N2), all other correlation values were > 0.92, in most cases approaching higher values like 0.98. Conclusion: The measurements of several layers of the retina and the choroid achieved at 13 locations presented a good repeatability and reproducibility. Manual quantification is still an alternative for the weaknesses of automatic segmentation. Locations of greatest concordance should be those used for the clinical control and monitoring. |
| format | Article |
| id | doaj-art-2c50b60fca7c40a28b09b075a44c9fef |
| institution | Kabale University |
| issn | 2008-2010 2008-322X |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Knowledge E |
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| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj-art-2c50b60fca7c40a28b09b075a44c9fef2025-01-13T10:02:33ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2021-07-0116338439210.18502/jovr.v16i3.9435jovr.v16i3.9435Manual Segmentation of 12 Layers of the Retina and Choroid through SD-OCT in Intermediate AMD: Repeatability and ReproducibilityPedro Camacho0Marco Dutra-Medeiros1Luís Salgueiro2Sílvia Sadio3Paulo C. Rosa4 H&TRC – Health & Technology Research Center, ESTeSL – Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal Retina Institute of Lisbon, Lisbon, Portugal Ophtalmology Institute Dr. Gama Pinto, Lisbon, Portugal Ophtalmology Institute Dr. Gama Pinto, Lisbon, Portugal Ophtalmology Institute Dr. Gama Pinto, Lisbon, PortugalAbstract Purpose: To evaluate the repeatability and reproducibility of the segmentation of 12 layers of the retina and the choroid, performed manually by SD-OCT, along the horizontal meridian at three different temporal moments, and to evaluate its concordance with the same measurements performed by two other operators in intermediate AMD. Methods: A cross-sectional study of 40 eyes from 40 subjects with intermediate AMD was conducted. The segmentation was performed manually, using SD-OCT. The 169 measurements per eye were repeated at three time points to study the intra-operator variability. The same process was repeated a single time by two different trained operators for the inter-operator variability. Results: Forty participants (28 women and 12 men) were enrolled in this study, with an average age of 76.4 ± 8.2 (range, 55–92 years). Overall, the maximum values of the various structures were found in the 3 mm of the macula. Intra-operator variability: the highest ICC values turned out to be discovered in thicker locations. Inter-operator variability: except correlation values of 0.826 (0.727; 0.898) obtained in the OPL (T2.5) and 0.634 (0.469; 0.771) obtained in the IPL (N2), all other correlation values were > 0.92, in most cases approaching higher values like 0.98. Conclusion: The measurements of several layers of the retina and the choroid achieved at 13 locations presented a good repeatability and reproducibility. Manual quantification is still an alternative for the weaknesses of automatic segmentation. Locations of greatest concordance should be those used for the clinical control and monitoring.https://doi.org/10.18502/jovr.v16i3.9435data accuracydiagnostic imagingmacular degeneration |
| spellingShingle | Pedro Camacho Marco Dutra-Medeiros Luís Salgueiro Sílvia Sadio Paulo C. Rosa Manual Segmentation of 12 Layers of the Retina and Choroid through SD-OCT in Intermediate AMD: Repeatability and Reproducibility Journal of Ophthalmic & Vision Research data accuracy diagnostic imaging macular degeneration |
| title | Manual Segmentation of 12 Layers of the Retina and Choroid through SD-OCT in Intermediate AMD: Repeatability and Reproducibility |
| title_full | Manual Segmentation of 12 Layers of the Retina and Choroid through SD-OCT in Intermediate AMD: Repeatability and Reproducibility |
| title_fullStr | Manual Segmentation of 12 Layers of the Retina and Choroid through SD-OCT in Intermediate AMD: Repeatability and Reproducibility |
| title_full_unstemmed | Manual Segmentation of 12 Layers of the Retina and Choroid through SD-OCT in Intermediate AMD: Repeatability and Reproducibility |
| title_short | Manual Segmentation of 12 Layers of the Retina and Choroid through SD-OCT in Intermediate AMD: Repeatability and Reproducibility |
| title_sort | manual segmentation of 12 layers of the retina and choroid through sd oct in intermediate amd repeatability and reproducibility |
| topic | data accuracy diagnostic imaging macular degeneration |
| url | https://doi.org/10.18502/jovr.v16i3.9435 |
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