RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis

RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis

Abstract Background Nuclear factor κB (NF-κB) activity is a central component of inflammatory and innate immune responses, which plays a crucial role in sepsis. The inhibition of NF-κB signaling and the IκB kinase (IKK) complex is important for understanding the control of innate immunity and regula...

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Main Authors: Shu-jie Pang, Tian-yi Jiang, Nai-guo Wang, Xiao-wen Cui, Hui Wang, Yu-fei Pan, Ning Yang, Li-wei Dong
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
IκB kinase β (IKKβ)
RNA polymerase II subunit 5-mediating protein (RMP)
NF-κB
Sepsis
Macrophage
Protein phosphatase 2A (PP2A)
Online Access:https://doi.org/10.1186/s12964-025-02278-w
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https://doi.org/10.1186/s12964-025-02278-w

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