Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging

Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging

Type II nuclear receptors (T2NRs) require heterodimerization with a common partner, the retinoid X receptor (RXR), to bind cognate DNA recognition sites in chromatin. Based on previous biochemical and overexpression studies, binding of T2NRs to chromatin is proposed to be regulated by competition fo...

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Bibliographic Details
Main Authors:	Liza Dahal, Thomas GW Graham, Gina M Dailey, Alec Heckert, Robert Tjian, Xavier Darzacq
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-01-01
Series:	eLife
Subjects:	single-molecule tracking nuclear receptors transcription factors gene regulatory networks molecular biophysics protein-protein interactions
Online Access:	https://elifesciences.org/articles/92979
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