Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK- mediated mitochondria protection in early diabetic retinopathy

Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK- mediated mitochondria protection in early diabetic retinopathy

Diabetic retinopathy (DR) is a blinding complication of microangiopathy. First-line therapeutic drugs are all focused on late-stage DR and have several side effects, which could not meet clinical needs. The plant-derived ginsenoside Ro (Ro) has a variety of effective anti-inflammatory, immune-regula...

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Bibliographic Details
Main Authors: Jia Liu, Yunqi Zhang, Xiaoyu Xu, Xi Dong, Yunfeng Pan, Xiaobo Sun, Yun Luo
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pharmacological Research
Subjects:
Ginsenoside Ro
Endothelial cell
Epac1/APMK pathway
Mitochondria damage
Diabetic retinopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824005073
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