Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial
Introduction Cardiovascular collapse is a common complication during tracheal intubation of critically ill adults. Whether administration of an intravenous fluid bolus prevents cardiovascular collapse during tracheal intubation remains uncertain. A prior randomised trial found fluid bolus administra...
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| author | Li Wang Tamer Hudali Shekhar Ghamande Megan Moore Bruno Pereira Christopher J Lindsell Wesley H Self Todd W Rice Matthew W Semler Kate O’Connor David B Page Victor E Ortega Aaron M Joffe Swati Gulati G Patel Heath D White Muhammad Ali Jonathan D Casey David R Janz Derek W Russell Derek J Vonderhaar Kevin M Dischert William S Stigler Emily Adams Kevin W Gibbs James M Dargin A M Joffe Akram Khan Simanta Dutta Janna S Landsperger Sarah W Robison Itay Bentov Joanne M Wozniak Susan Stempek Olivia F Krol Matthew E Prekker Brian E Driver Joseph M Brewer Christopher John Lindsell David Janz Stephen P Peters Rita N Bakhru Scott Bauer Christina R Bellinger Amanda M Brown Blair Brown Jerri Brown Caitlin Bumgarner Wendy Butcher Megan Caudle Arjun B Chatterjee David J Chodos Gerardo Corcino Nathan S Cutler Travis L Dotson Daniel C Files Jonathan L Forbes John P Gaillard Katherine A Gershner Shannon Ginty Kiadrick R Hood April Hazelwood Katherine Hendricks Kelly Jacobus Jonathan T Jaffe Stacy Kay Chad A Kloefkorn Jennifer Krall Margo T Lannan Cornelia Lane Cynthia Lanning Jessica Lyons William I Mariencheck Chad R Marion Matthew A Maslonka Sara McClintock Nathaniel M Meier Matthew C Miles Peter J Miller Sophia Mitchell Wendy C Moore Katherine Moss Andrew M Namen Dustin L Norton Stella B Ogake Jill A Ohar Jessica A Palakshappa Rodolfo M Pascual Sandi Pascual Aaron Pickens Adam R Schertz Matt Strong Alexander O Sy Braghadheeswar Thyagarajan Amy Townsend Russell Worthen Michael Wlodarski Charles Yarbrough Caroline York Bradley Lloyd James Dargin Joanne Wozniak Christopher Adler Ahmed Agameya Michael Colancecco Daniel Fitelson Joshua Giaccotto Gena Han Louise Kane Ezra Miller Timothy Noland Jaqueline Price Joseph Plourde Fraser Mackay Laura Mahoney Avignat Patel Michael Plourde Zena Saadeh Sara Shadchehr Sandeep Somalaraju Eleanor Summerhill Ryan Webster Jordan Winnicki Ekaterina Yavarovich Sheetal Gandotra Anna Altz-Stamm Cristina Bardita Mary Clay Boone Joe W Chiles Kristina Collins Abby Drescher Kevin G Dsouza Janna Dunn Stacy Ejem Josh Gautney Nicole Harris Savannah Herder R Chad Wade Rutwij Joshi Daniel Kelmenson Anne Merrill Mason Scott R Merriman Takudzwa Mkorombindo Jada Nowak D Sheylan Lisa Sarratt Tabitha Stewart Kadambari Vijaykumar Gina White Micah R Whitson Christopher Barnes Andrew M Walters Alejandro C Arroliga Tasnim Lat Stephanie Nonas Milad K Jouzestani Raya Adi Chandani Anandkat Hanae Benchbani Matthew G Drake Makrina N Kamel Ramanpreet Randhawa Jessica L Tsui |
| author_facet | Li Wang Tamer Hudali Shekhar Ghamande Megan Moore Bruno Pereira Christopher J Lindsell Wesley H Self Todd W Rice Matthew W Semler Kate O’Connor David B Page Victor E Ortega Aaron M Joffe Swati Gulati G Patel Heath D White Muhammad Ali Jonathan D Casey David R Janz Derek W Russell Derek J Vonderhaar Kevin M Dischert William S Stigler Emily Adams Kevin W Gibbs James M Dargin A M Joffe Akram Khan Simanta Dutta Janna S Landsperger Sarah W Robison Itay Bentov Joanne M Wozniak Susan Stempek Olivia F Krol Matthew E Prekker Brian E Driver Joseph M Brewer Christopher John Lindsell David Janz Stephen P Peters Rita N Bakhru Scott Bauer Christina R Bellinger Amanda M Brown Blair Brown Jerri Brown Caitlin Bumgarner Wendy Butcher Megan Caudle Arjun B Chatterjee David J Chodos Gerardo Corcino Nathan S Cutler Travis L Dotson Daniel C Files Jonathan L Forbes John P Gaillard Katherine A Gershner Shannon Ginty Kiadrick R Hood April Hazelwood Katherine Hendricks Kelly Jacobus Jonathan T Jaffe Stacy Kay Chad A Kloefkorn Jennifer Krall Margo T Lannan Cornelia Lane Cynthia Lanning Jessica Lyons William I Mariencheck Chad R Marion Matthew A Maslonka Sara McClintock Nathaniel M Meier Matthew C Miles Peter J Miller Sophia Mitchell Wendy C Moore Katherine Moss Andrew M Namen Dustin L Norton Stella B Ogake Jill A Ohar Jessica A Palakshappa Rodolfo M Pascual Sandi Pascual Aaron Pickens Adam R Schertz Matt Strong Alexander O Sy Braghadheeswar Thyagarajan Amy Townsend Russell Worthen Michael Wlodarski Charles Yarbrough Caroline York Bradley Lloyd James Dargin Joanne Wozniak Christopher Adler Ahmed Agameya Michael Colancecco Daniel Fitelson Joshua Giaccotto Gena Han Louise Kane Ezra Miller Timothy Noland Jaqueline Price Joseph Plourde Fraser Mackay Laura Mahoney Avignat Patel Michael Plourde Zena Saadeh Sara Shadchehr Sandeep Somalaraju Eleanor Summerhill Ryan Webster Jordan Winnicki Ekaterina Yavarovich Sheetal Gandotra Anna Altz-Stamm Cristina Bardita Mary Clay Boone Joe W Chiles Kristina Collins Abby Drescher Kevin G Dsouza Janna Dunn Stacy Ejem Josh Gautney Nicole Harris Savannah Herder R Chad Wade Rutwij Joshi Daniel Kelmenson Anne Merrill Mason Scott R Merriman Takudzwa Mkorombindo Jada Nowak D Sheylan Lisa Sarratt Tabitha Stewart Kadambari Vijaykumar Gina White Micah R Whitson Christopher Barnes Andrew M Walters Alejandro C Arroliga Tasnim Lat Stephanie Nonas Milad K Jouzestani Raya Adi Chandani Anandkat Hanae Benchbani Matthew G Drake Makrina N Kamel Ramanpreet Randhawa Jessica L Tsui |
| collection | DOAJ |
| description | Introduction Cardiovascular collapse is a common complication during tracheal intubation of critically ill adults. Whether administration of an intravenous fluid bolus prevents cardiovascular collapse during tracheal intubation remains uncertain. A prior randomised trial found fluid bolus administration to be ineffective overall but suggested potential benefit for patients receiving positive pressure ventilation during tracheal intubation.Methods and analysis The PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) trial is a prospective, multi-centre, non-blinded randomised trial being conducted in 13 academic intensive care units in the USA. The trial will randomise 1065 critically ill adults undergoing tracheal intubation with planned use of positive pressure ventilation (non-invasive ventilation or bag-mask ventilation) between induction and laryngoscopy to receive 500 mL of intravenous crystalloid or no intravenous fluid bolus. The primary outcome is cardiovascular collapse, defined as any of: systolic blood pressure <65 mm Hg, new or increased vasopressor administration between induction and 2 min after intubation, or cardiac arrest or death between induction and 1 hour after intubation. The primary analysis will be an unadjusted, intention-to-treat comparison of the primary outcome between patients randomised to fluid bolus administration and patients randomised to no fluid bolus administration using a χ2 test. The sole secondary outcome is 28-day in-hospital mortality. Enrolment began on 1 February 2019 and is expected to conclude in June 2020.Ethics and dissemination The trial was approved by either the central institutional review board at Vanderbilt University Medical Center or the local institutional review board at each trial site. Results will be submitted for publication in a peer-reviewed journal and presented at scientific conferences.Trial registration number NCT03787732. |
| format | Article |
| id | doaj-art-2ba2c5187514437a8f6016f526ab37ae |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-2ba2c5187514437a8f6016f526ab37ae2025-01-08T15:55:08ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2019-036671Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial 0Li Wang1Tamer HudaliShekhar Ghamande2Megan Moore3Bruno Pereira4Christopher J Lindsell5Wesley H Self6Todd W Rice7Matthew W Semler8Kate O’ConnorDavid B Page9Victor E Ortega10Aaron M Joffe11Swati Gulati12G Patel13Heath D White14Muhammad Ali15Jonathan D Casey16David R Janz17Derek W Russell18Derek J Vonderhaar19Kevin M DischertWilliam S StiglerEmily Adams20Kevin W Gibbs21James M Dargin22A M Joffe23Akram Khan24Simanta Dutta25Janna S Landsperger26Sarah W Robison27Itay Bentov28Joanne M Wozniak29Susan Stempek30Olivia F Krol31Matthew E Prekker32Brian E Driver33Joseph M Brewer34Christopher John Lindsell35David Janz36Stephen P PetersRita N BakhruScott BauerChristina R BellingerAmanda M BrownBlair BrownJerri BrownCaitlin BumgarnerWendy ButcherMegan CaudleArjun B ChatterjeeDavid J ChodosGerardo CorcinoNathan S CutlerTravis L DotsonDaniel C FilesJonathan L ForbesJohn P Gaillard37Katherine A GershnerShannon GintyKiadrick R HoodApril HazelwoodKatherine HendricksKelly JacobusJonathan T JaffeStacy KayChad A KloefkornJennifer KrallMargo T LannanCornelia LaneCynthia LanningJessica LyonsWilliam I MariencheckChad R MarionMatthew A MaslonkaSara McClintockNathaniel M MeierMatthew C MilesPeter J MillerSophia MitchellWendy C MooreKatherine MossAndrew M NamenDustin L NortonStella B OgakeJill A OharJessica A PalakshappaRodolfo M PascualSandi PascualAaron PickensAdam R SchertzMatt StrongAlexander O SyBraghadheeswar ThyagarajanAmy TownsendRussell WorthenMichael WlodarskiCharles YarbroughCaroline YorkBradley LloydJames DarginJoanne WozniakChristopher AdlerAhmed AgameyaMichael ColanceccoDaniel FitelsonJoshua GiaccottoGena HanLouise KaneEzra MillerTimothy NolandJaqueline PriceJoseph PlourdeFraser MackayLaura MahoneyAvignat PatelMichael PlourdeZena SaadehSara ShadchehrSandeep SomalarajuEleanor SummerhillRyan WebsterJordan WinnickiEkaterina YavarovichSheetal Gandotra38Anna Altz-StammCristina BarditaMary Clay BooneJoe W ChilesKristina CollinsAbby DrescherKevin G DsouzaJanna DunnStacy EjemJosh GautneyNicole HarrisSavannah HerderR Chad WadeRutwij JoshiDaniel KelmensonAnne Merrill MasonScott R MerrimanTakudzwa MkorombindoJada NowakD SheylanLisa SarrattTabitha StewartKadambari VijaykumarGina WhiteMicah R Whitson39Christopher BarnesAndrew M WaltersAlejandro C ArroligaTasnim LatStephanie NonasMilad K JouzestaniRaya AdiChandani AnandkatHanae BenchbaniMatthew G DrakeMakrina N KamelRamanpreet RandhawaJessica L TsuiGENYO, Pfizer-University, Granada, Spain, Granada, Spain8Cleveland Clinic and Lerner College of Medicine, Cleveland, OH, USADepartment of Medicine, Division of Pulmonary Disease and Critical Care Medicine, Baylor Scott & White Medical Center, Temple, Texas, USAInjury Prevention and Research Center, Harborview Medical Center, Seattle, Washington, USAClinical Research and Innovation Direction, University Hospital of Clermont Ferrand, Clermont-Ferrand, France, Clermont-Ferrand, France5 Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USADepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USAprofessor of medicineDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USAEarle A Chiles Research Institute, Portland, Oregon, USAInternal Medicine, Wake Forest Health Sciences, Winston-Salem, North Carolina, USADepartment of Anesthesiology and Pain Medicine, Harborview Medical Center, Seattle, Washington, USA3 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Womens Hospital, Boston, Massachusetts, USABarking, Havering and Redbridge University Hospitals NHS Trust, London, UKDepartment of Medicine, Division of Pulmonary Disease and Critical Care Medicine, Baylor Scott & White Medical Center, Temple, Texas, USAWilmer Eye Institute, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, USADivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA4 Department of Medicine, Section of Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University School of Medicine in New Orleans, New Orleans, Louisiana, USADepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Pulmonary/Critical Care Medicine, Ochsner Health System, New Orleans, Louisiana, USAmedical studentDepartment of Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest School of Medicine, Winston-Salem, North Carolina, USADepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts, USADepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USA4 Department of Medicine, Oregon Health & Science University, Portland, Oregon, USADepartment of Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest School of Medicine, Winston-Salem, North Carolina, USADepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USADepartment of Medicine, Division of Pulmonary, Allergy, & Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USADepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts, USADepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts, USADepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University School of Medicine, Portland, Oregon, USADepartment of Emergency Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, USADepartment of Emergency Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, USADepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USADepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USASection of Pulmonary/Critical Care Medicine & Allergy/Immunology, Louisiana State University, New Orleans, Louisiana, USADepartment of Emergency Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USADepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Emergency Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USAIntroduction Cardiovascular collapse is a common complication during tracheal intubation of critically ill adults. Whether administration of an intravenous fluid bolus prevents cardiovascular collapse during tracheal intubation remains uncertain. A prior randomised trial found fluid bolus administration to be ineffective overall but suggested potential benefit for patients receiving positive pressure ventilation during tracheal intubation.Methods and analysis The PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) trial is a prospective, multi-centre, non-blinded randomised trial being conducted in 13 academic intensive care units in the USA. The trial will randomise 1065 critically ill adults undergoing tracheal intubation with planned use of positive pressure ventilation (non-invasive ventilation or bag-mask ventilation) between induction and laryngoscopy to receive 500 mL of intravenous crystalloid or no intravenous fluid bolus. The primary outcome is cardiovascular collapse, defined as any of: systolic blood pressure <65 mm Hg, new or increased vasopressor administration between induction and 2 min after intubation, or cardiac arrest or death between induction and 1 hour after intubation. The primary analysis will be an unadjusted, intention-to-treat comparison of the primary outcome between patients randomised to fluid bolus administration and patients randomised to no fluid bolus administration using a χ2 test. The sole secondary outcome is 28-day in-hospital mortality. Enrolment began on 1 February 2019 and is expected to conclude in June 2020.Ethics and dissemination The trial was approved by either the central institutional review board at Vanderbilt University Medical Center or the local institutional review board at each trial site. Results will be submitted for publication in a peer-reviewed journal and presented at scientific conferences.Trial registration number NCT03787732.https://bmjopen.bmj.com/content/10/9/e036671.full |
| spellingShingle | Li Wang Tamer Hudali Shekhar Ghamande Megan Moore Bruno Pereira Christopher J Lindsell Wesley H Self Todd W Rice Matthew W Semler Kate O’Connor David B Page Victor E Ortega Aaron M Joffe Swati Gulati G Patel Heath D White Muhammad Ali Jonathan D Casey David R Janz Derek W Russell Derek J Vonderhaar Kevin M Dischert William S Stigler Emily Adams Kevin W Gibbs James M Dargin A M Joffe Akram Khan Simanta Dutta Janna S Landsperger Sarah W Robison Itay Bentov Joanne M Wozniak Susan Stempek Olivia F Krol Matthew E Prekker Brian E Driver Joseph M Brewer Christopher John Lindsell David Janz Stephen P Peters Rita N Bakhru Scott Bauer Christina R Bellinger Amanda M Brown Blair Brown Jerri Brown Caitlin Bumgarner Wendy Butcher Megan Caudle Arjun B Chatterjee David J Chodos Gerardo Corcino Nathan S Cutler Travis L Dotson Daniel C Files Jonathan L Forbes John P Gaillard Katherine A Gershner Shannon Ginty Kiadrick R Hood April Hazelwood Katherine Hendricks Kelly Jacobus Jonathan T Jaffe Stacy Kay Chad A Kloefkorn Jennifer Krall Margo T Lannan Cornelia Lane Cynthia Lanning Jessica Lyons William I Mariencheck Chad R Marion Matthew A Maslonka Sara McClintock Nathaniel M Meier Matthew C Miles Peter J Miller Sophia Mitchell Wendy C Moore Katherine Moss Andrew M Namen Dustin L Norton Stella B Ogake Jill A Ohar Jessica A Palakshappa Rodolfo M Pascual Sandi Pascual Aaron Pickens Adam R Schertz Matt Strong Alexander O Sy Braghadheeswar Thyagarajan Amy Townsend Russell Worthen Michael Wlodarski Charles Yarbrough Caroline York Bradley Lloyd James Dargin Joanne Wozniak Christopher Adler Ahmed Agameya Michael Colancecco Daniel Fitelson Joshua Giaccotto Gena Han Louise Kane Ezra Miller Timothy Noland Jaqueline Price Joseph Plourde Fraser Mackay Laura Mahoney Avignat Patel Michael Plourde Zena Saadeh Sara Shadchehr Sandeep Somalaraju Eleanor Summerhill Ryan Webster Jordan Winnicki Ekaterina Yavarovich Sheetal Gandotra Anna Altz-Stamm Cristina Bardita Mary Clay Boone Joe W Chiles Kristina Collins Abby Drescher Kevin G Dsouza Janna Dunn Stacy Ejem Josh Gautney Nicole Harris Savannah Herder R Chad Wade Rutwij Joshi Daniel Kelmenson Anne Merrill Mason Scott R Merriman Takudzwa Mkorombindo Jada Nowak D Sheylan Lisa Sarratt Tabitha Stewart Kadambari Vijaykumar Gina White Micah R Whitson Christopher Barnes Andrew M Walters Alejandro C Arroliga Tasnim Lat Stephanie Nonas Milad K Jouzestani Raya Adi Chandani Anandkat Hanae Benchbani Matthew G Drake Makrina N Kamel Ramanpreet Randhawa Jessica L Tsui Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial BMJ Open |
| title | Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial |
| title_full | Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial |
| title_fullStr | Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial |
| title_full_unstemmed | Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial |
| title_short | Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial |
| title_sort | protocol and statistical analysis plan for the preventing cardiovascular collapse with administration of fluid resuscitation during induction and intubation prepare ii randomised clinical trial |
| url | https://bmjopen.bmj.com/content/10/9/e036671.full |
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protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT stacykay protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT chadakloefkorn protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jenniferkrall protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT margotlannan protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT cornelialane protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT cynthialanning protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jessicalyons protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT williamimariencheck protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT chadrmarion protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT matthewamaslonka protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT saramcclintock protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT nathanielmmeier protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT matthewcmiles protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT peterjmiller protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT sophiamitchell protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT wendycmoore protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT katherinemoss protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT andrewmnamen protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT dustinlnorton protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT stellabogake protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jillaohar protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jessicaapalakshappa protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT rodolfompascual protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT sandipascual protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT aaronpickens protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT adamrschertz protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT mattstrong protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT alexanderosy protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT braghadheeswarthyagarajan protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT amytownsend protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT russellworthen protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT michaelwlodarski protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT charlesyarbrough protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT carolineyork protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT bradleylloyd protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jamesdargin protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT joannewozniak protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT christopheradler protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT ahmedagameya protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT michaelcolancecco protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT danielfitelson protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT joshuagiaccotto protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT genahan protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT louisekane protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT ezramiller protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT timothynoland protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jaquelineprice protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT josephplourde protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT frasermackay protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT lauramahoney protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT avignatpatel protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT michaelplourde protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT zenasaadeh protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT sarashadchehr protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT sandeepsomalaraju protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT eleanorsummerhill protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT ryanwebster protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jordanwinnicki protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT ekaterinayavarovich protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT sheetalgandotra protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT annaaltzstamm protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT cristinabardita protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT maryclayboone protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT joewchiles protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT kristinacollins protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT abbydrescher protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT kevingdsouza protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jannadunn protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT stacyejem protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT joshgautney protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT nicoleharris protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT savannahherder protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT rchadwade protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT rutwijjoshi protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT danielkelmenson protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT annemerrillmason protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT scottrmerriman protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT takudzwamkorombindo protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jadanowak protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT dsheylan protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT lisasarratt protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT tabithastewart protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT kadambarivijaykumar protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT ginawhite protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT micahrwhitson protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT christopherbarnes protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT andrewmwalters protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT alejandrocarroliga protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT tasnimlat protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT stephanienonas protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT miladkjouzestani protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT rayaadi protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT chandanianandkat protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT hanaebenchbani protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT matthewgdrake protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT makrinankamel protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT ramanpreetrandhawa protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial AT jessicaltsui protocolandstatisticalanalysisplanforthepreventingcardiovascularcollapsewithadministrationoffluidresuscitationduringinductionandintubationprepareiirandomisedclinicaltrial |