In vitro and in vivo studies on exogenous polyamines and α-difluoromethylornithine to enhance bone formation and suppress osteoclast differentiation

In vitro and in vivo studies on exogenous polyamines and α-difluoromethylornithine to enhance bone formation and suppress osteoclast differentiation

Abstract Exogenous polyamines, including putrescine (PUT), spermidine (SPD), and spermine (SPM), and the irreversible inhibitor of the rate-limiting enzyme ornithine decarboxylase (ODC) of polyamine biosynthesis, α-difluoromethylornithine (DFMO), are implicated as stimulants for bone formation. We d...

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Main Authors: Chien-Ching Lee, Chia-Chun Chuang, Chung-Hwan Chen, Yuan-Pin Huang, Chiao-Yi Chang, Pei-Yi Tung, Mon-Juan Lee
Format: Article
Language:English
Published: Springer 2024-06-01
Series:Amino Acids
Subjects:
Polyamines
α-difluoromethylornithine (DFMO)
Osteogenic differentiation
Osteoclastogenic differentiation
Ovariectomized rat
Osteoporosis
Online Access:https://doi.org/10.1007/s00726-024-03403-8
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https://doi.org/10.1007/s00726-024-03403-8

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