Predictive analysis of solubility data with pressure and temperature in assessing nanomedicine preparation via supercritical carbon dioxide

Abstract This work presents a comprehensive study on the prediction of phenytoin solubility at supercritical state using advanced techniques including machine learning analysis. The solubility of small-molecule pharmaceutical was analyzed and calculated to enhance its solubility and bioavailability...

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Bibliographic Details
Main Authors: Hashem O. Alsaab, Yusuf S. Althobaiti
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-16577-2
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