Genetic deregulation of REL in germinal center B cells induces generation of a pool of lymphoma precursor cells

Genetic deregulation of REL in germinal center B cells induces generation of a pool of lymphoma precursor cells

Abstract: In diffuse large B-cell lymphomas (DLBCLs), gains and amplifications of the 2p15-16 region, which always encompass the REL gene, are mostly restricted to the germinal center (GC) B-cell DLBCL subtype (GCB-DLBCL) for which c-Rel is the pivotal Rel/NF−κΒ subunit. Although REL plays a key rol...

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Main Authors: Léa Prévaud, Karima Ferhat, Dilara Sensoy, Ophélie Téteau, Tiffany Marchiol, Quentin Lemasson, Catherine Ouk, Claire Carrion, Michel Cogné, Jean Feuillard, Christelle Vincent-Fabert, Nathalie Faumont
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925002393
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