Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models
Abstract Chronic rotator cuff tears (RCTs) are one of the most common injuries of shoulder pain. Despite the recent advances in surgical techniques and improved clinical outcomes of arthroscopically repaired rotator cuffs (RCs), complete functional recovery—without retear—of the RC tendon through te...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Bioengineering & Translational Medicine |
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| Online Access: | https://doi.org/10.1002/btm2.10376 |
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| author | Yonghyun Gwon Woochan Kim Sunho Park Yang‐Kyung Kim Hyoseong Kim Myung‐Sun Kim Jangho Kim |
| author_facet | Yonghyun Gwon Woochan Kim Sunho Park Yang‐Kyung Kim Hyoseong Kim Myung‐Sun Kim Jangho Kim |
| author_sort | Yonghyun Gwon |
| collection | DOAJ |
| description | Abstract Chronic rotator cuff tears (RCTs) are one of the most common injuries of shoulder pain. Despite the recent advances in surgical techniques and improved clinical outcomes of arthroscopically repaired rotator cuffs (RCs), complete functional recovery—without retear—of the RC tendon through tendon‐to‐bone interface (TBI) regeneration remains a key clinical goal to be achieved. Inspired by the highly organized nanostructured extracellular matrix in RC tendon tissue, we propose herein a tissue‐engineered tendon nano‐construct (TNC) for RC tendon regeneration. When compared with two currently used strategies (i.e., transosseous sutures and stem cell injections), our nano‐construct facilitated more significant healing of all parts of the TBI (i.e., tendon, fibrocartilages, and bone) in both rabbit and pig RCT models owing to its enhancements in cell proliferation and differentiation, protein expression, and growth factor secretion. Overall, our findings demonstrate the high potential of this transplantable tendon nano‐construct for clinical repair of chronic RCTs. |
| format | Article |
| id | doaj-art-2b5d1a22cc0c4fd4ba18b053fdbd8707 |
| institution | Kabale University |
| issn | 2380-6761 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj-art-2b5d1a22cc0c4fd4ba18b053fdbd87072024-11-21T05:16:03ZengWileyBioengineering & Translational Medicine2380-67612023-01-0181n/an/a10.1002/btm2.10376Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal modelsYonghyun Gwon0Woochan Kim1Sunho Park2Yang‐Kyung Kim3Hyoseong Kim4Myung‐Sun Kim5Jangho Kim6Department of Convergence Biosystems Engineering Chonnam National University Gwangju Republic of KoreaDepartment of Convergence Biosystems Engineering Chonnam National University Gwangju Republic of KoreaDepartment of Convergence Biosystems Engineering Chonnam National University Gwangju Republic of KoreaDepartment of Physical and Rehabilitation Medicine Chonnam National University Medical School & Hospital Gwangju Republic of KoreaDepartment of Convergence Biosystems Engineering Chonnam National University Gwangju Republic of KoreaDepartment of Orthopaedic Surgery, Chonnam National University Medical School & Hospital Gwangju Republic of KoreaDepartment of Convergence Biosystems Engineering Chonnam National University Gwangju Republic of KoreaAbstract Chronic rotator cuff tears (RCTs) are one of the most common injuries of shoulder pain. Despite the recent advances in surgical techniques and improved clinical outcomes of arthroscopically repaired rotator cuffs (RCs), complete functional recovery—without retear—of the RC tendon through tendon‐to‐bone interface (TBI) regeneration remains a key clinical goal to be achieved. Inspired by the highly organized nanostructured extracellular matrix in RC tendon tissue, we propose herein a tissue‐engineered tendon nano‐construct (TNC) for RC tendon regeneration. When compared with two currently used strategies (i.e., transosseous sutures and stem cell injections), our nano‐construct facilitated more significant healing of all parts of the TBI (i.e., tendon, fibrocartilages, and bone) in both rabbit and pig RCT models owing to its enhancements in cell proliferation and differentiation, protein expression, and growth factor secretion. Overall, our findings demonstrate the high potential of this transplantable tendon nano‐construct for clinical repair of chronic RCTs.https://doi.org/10.1002/btm2.10376chronic rotator cuff tearslarge animal modeltendon nano‐constructtendon regenerationtendon‐to‐bone interface |
| spellingShingle | Yonghyun Gwon Woochan Kim Sunho Park Yang‐Kyung Kim Hyoseong Kim Myung‐Sun Kim Jangho Kim Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models Bioengineering & Translational Medicine chronic rotator cuff tears large animal model tendon nano‐construct tendon regeneration tendon‐to‐bone interface |
| title | Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models |
| title_full | Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models |
| title_fullStr | Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models |
| title_full_unstemmed | Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models |
| title_short | Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models |
| title_sort | tissue engineered tendon nano constructs for repair of chronic rotator cuff tears in large animal models |
| topic | chronic rotator cuff tears large animal model tendon nano‐construct tendon regeneration tendon‐to‐bone interface |
| url | https://doi.org/10.1002/btm2.10376 |
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