Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

With the objective of finding new classes of cognitive enhancers with potential for the treatment of neurodegenerative disorders, such as Alzheimer's disease, small molecule inhibitors of insulin-regulated aminopeptidase (IRAP) were designed and synthesized. IRAP is a member of the M1 family of...

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Bibliographic Details
Main Authors: Julia Beveridge, Marcus Söderström, Rubén Prieto-Díaz, Hugo Gutierrez-de-Teran, Luke R. Odell, Mathias Hallberg, Mats Larhed, Johan Gising
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Insulin Regulated Aminopeptidase
Inhibitors
Hydroxamic acids
Free energy perturbations
Structure activity relationships
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424000876
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