Surgical Management of Desmoid Tumors—Patient Selection, Timing, and Approach
Desmoid tumors are rare, deep-seated myofibroblastic tumors with an unpredictable course, ranging from spontaneous regression to infiltrative growth and locally aggressive behavior, but without metastatic potential. Over the past few decades, advances in understanding their natural history, underlyi...
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| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/7/408 |
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| author | Catherine Sarre Lazcano Alessandro Gronchi |
| author_facet | Catherine Sarre Lazcano Alessandro Gronchi |
| author_sort | Catherine Sarre Lazcano |
| collection | DOAJ |
| description | Desmoid tumors are rare, deep-seated myofibroblastic tumors with an unpredictable course, ranging from spontaneous regression to infiltrative growth and locally aggressive behavior, but without metastatic potential. Over the past few decades, advances in understanding their natural history, underlying molecular pathways, and patient care priorities have shifted the treatment paradigm from upfront surgical resection to initial active surveillance, with further treatment dictated by continuous disease progression or associated symptoms. However, there are still specific scenarios where surgery continues to play an important role in locoregional treatment and symptom control. This article will focus on current treatment strategies and surgical indications in adult patients with desmoid tumors, emphasizing patient selection, anatomic site-specific considerations, and surgical technique. Understanding the nuanced role of surgery within the growing treatment landscape is key for individualized patient care in a multidisciplinary setting to optimize quality of life and long-term outcomes. |
| format | Article |
| id | doaj-art-2ad5287f7a694cbb937cbb1e80e0c469 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-2ad5287f7a694cbb937cbb1e80e0c4692025-08-20T03:58:31ZengMDPI AGCurrent Oncology1198-00521718-77292025-07-0132740810.3390/curroncol32070408Surgical Management of Desmoid Tumors—Patient Selection, Timing, and ApproachCatherine Sarre Lazcano0Alessandro Gronchi1Division of Surgical Oncology, Department of Surgery, University of Toronto, Toronto, ON M5S 1A1, CanadaSarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyDesmoid tumors are rare, deep-seated myofibroblastic tumors with an unpredictable course, ranging from spontaneous regression to infiltrative growth and locally aggressive behavior, but without metastatic potential. Over the past few decades, advances in understanding their natural history, underlying molecular pathways, and patient care priorities have shifted the treatment paradigm from upfront surgical resection to initial active surveillance, with further treatment dictated by continuous disease progression or associated symptoms. However, there are still specific scenarios where surgery continues to play an important role in locoregional treatment and symptom control. This article will focus on current treatment strategies and surgical indications in adult patients with desmoid tumors, emphasizing patient selection, anatomic site-specific considerations, and surgical technique. Understanding the nuanced role of surgery within the growing treatment landscape is key for individualized patient care in a multidisciplinary setting to optimize quality of life and long-term outcomes.https://www.mdpi.com/1718-7729/32/7/408desmoid tumoraggressive fibromatosissurgerymarginsfunctional outcomes |
| spellingShingle | Catherine Sarre Lazcano Alessandro Gronchi Surgical Management of Desmoid Tumors—Patient Selection, Timing, and Approach Current Oncology desmoid tumor aggressive fibromatosis surgery margins functional outcomes |
| title | Surgical Management of Desmoid Tumors—Patient Selection, Timing, and Approach |
| title_full | Surgical Management of Desmoid Tumors—Patient Selection, Timing, and Approach |
| title_fullStr | Surgical Management of Desmoid Tumors—Patient Selection, Timing, and Approach |
| title_full_unstemmed | Surgical Management of Desmoid Tumors—Patient Selection, Timing, and Approach |
| title_short | Surgical Management of Desmoid Tumors—Patient Selection, Timing, and Approach |
| title_sort | surgical management of desmoid tumors patient selection timing and approach |
| topic | desmoid tumor aggressive fibromatosis surgery margins functional outcomes |
| url | https://www.mdpi.com/1718-7729/32/7/408 |
| work_keys_str_mv | AT catherinesarrelazcano surgicalmanagementofdesmoidtumorspatientselectiontimingandapproach AT alessandrogronchi surgicalmanagementofdesmoidtumorspatientselectiontimingandapproach |