RM2 and DB15 analogues bearing [177Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

RM2 and DB15 analogues bearing [177Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Abstract Background Bombesin analogues are gaining popularity as GRPR-targeting theranostic agents aiming to provide molecular tools for a patient-tailored management. We previously reported on two series of DOTAGA-bearing GRPR-antagonists, based on either [NMe-Gly11]RM26 (DOTAGA-X-DPhe-Gln-Trp-Ala-...

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Bibliographic Details
Main Authors: Panagiotis Kanellopoulos, Athanasios Bitzios, Ivan Zelepukin, Ekaterina Bezverkhniaia, Theodosia Maina, Berthold A. Nock, Vladimir Tolmachev, Anna Orlova
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
GRPR
Bombesin
Lu-177
Radiotherapy
PRRT
Pharmacokinetics
Online Access:https://doi.org/10.1186/s41181-025-00374-3
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https://doi.org/10.1186/s41181-025-00374-3

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