Toward alpha‐synuclein seed amplification assay in clinical practice

Toward alpha‐synuclein seed amplification assay in clinical practice

Abstract INTRODUCTION Seed amplification assays (SAAs) demonstrate remarkable diagnostic performance in alpha‐synucleinopathies. However, existing protocols lack accessibility in routine laboratories, mainly due to the requirement for in‐house production of recombinant alpha‐synuclein (aSyn). This s...

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Main Authors: Mathieu Verdurand, Flora Kaczorowski, Sophie Dautricourt, Virginie Desestret, Maïté Formaglio, Hélène Mollion, Gil Petitnicolas, Ali Afifi, Anthony Fourier, Antoine Garnier‐Crussard, Isabelle Quadrio
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
alpha‐synuclein (α‐synuclein)
aSyn
biomarker
brain homogenate (BH)
cerebrospinal fluid (CSF)
dementia with Lewy bodies (DLB)
Online Access:https://doi.org/10.1002/dad2.70066
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https://doi.org/10.1002/dad2.70066

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