Heparin-binding EGF-like growth factor: mechanisms of biological activity and potential therapeutic applications

Heparin-binding EGF-like growth factor: mechanisms of biological activity and potential therapeutic applications

The diphtheria toxin receptor on sensitive mammalian cells is known as the membrane anchored precursor of heparin-binding EGF-like growth factor (HB-EGF). When the precursor is cleaved by metalloproteinases, a soluble form (sHB-EGF) is formed that can bind to the EGF receptors, resulting in activati...

Full description

Saved in:
Bibliographic Details
Main Authors: L. M. Dronko, T. M. Lutsenko, N. V. Korotkevych, I. O. Vovk, D. A. Zhukova, S. I. Romaniuk, A. A. Siromolot, A. J. Labyntsev, D. V. Kolybo
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2024-10-01
Series:The Ukrainian Biochemical Journal
Subjects:
cell proliferation
diphtheria toxin
egf receptor
heparin-binding egf-like growth factor
signal transduction
wound healing
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2024/10/Dronko_96_5.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://ukrbiochemjournal.org/wp-content/uploads/2024/10/Dronko_96_5.pdf

Similar Items