Safety of Mesenchymal Stem Cells for Clinical Application
Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded M...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/652034 |
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| _version_ | 1849307501573439488 |
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| author | Youwei Wang Zhi-bo Han Yong-ping Song Zhong Chao Han |
| author_facet | Youwei Wang Zhi-bo Han Yong-ping Song Zhong Chao Han |
| author_sort | Youwei Wang |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-term in vitro expansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs. |
| format | Article |
| id | doaj-art-2a85fd1fda2046a9af6c67c4fb482899 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-2a85fd1fda2046a9af6c67c4fb4828992025-08-20T03:54:43ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/652034652034Safety of Mesenchymal Stem Cells for Clinical ApplicationYouwei Wang0Zhi-bo Han1Yong-ping Song2Zhong Chao Han3State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, ChinaState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, ChinaDepartment of Hematology, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450052, ChinaState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, ChinaMesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-term in vitro expansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs.http://dx.doi.org/10.1155/2012/652034 |
| spellingShingle | Youwei Wang Zhi-bo Han Yong-ping Song Zhong Chao Han Safety of Mesenchymal Stem Cells for Clinical Application Stem Cells International |
| title | Safety of Mesenchymal Stem Cells for Clinical Application |
| title_full | Safety of Mesenchymal Stem Cells for Clinical Application |
| title_fullStr | Safety of Mesenchymal Stem Cells for Clinical Application |
| title_full_unstemmed | Safety of Mesenchymal Stem Cells for Clinical Application |
| title_short | Safety of Mesenchymal Stem Cells for Clinical Application |
| title_sort | safety of mesenchymal stem cells for clinical application |
| url | http://dx.doi.org/10.1155/2012/652034 |
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