Immunocompetent cell targeting by food-additive titanium dioxide

Abstract Food-grade titanium dioxide (fgTiO2) is a bio-persistent particle under intense regulatory scrutiny. Yet paradoxically, the only known cell reservoirs for fgTiO2 are graveyard intestinal pigment cells which are metabolically and immunologically quiescent. Here we identify immunocompetent ce...

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Main Authors: John W. Wills, Alicja Dabrowska, Jack Robertson, Michelle Miniter, Sebastian Riedle, Huw D. Summers, Rachel E. Hewitt, Adeeba Fathima, Alessandra Barreto da Silva, Carlos A. P. Bastos, Stuart Micklethwaite, Åsa V. Keita, Johan D. Söderholm, Nicole C. Roy, Don Otter, Ravin Jugdaohsingh, Pietro Mastroeni, Andy P. Brown, Paul Rees, Jonathan J. Powell
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60248-9
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