Single-cell transcriptomics uncovers key immune drivers of vaccine efficacy in cattle

Single-cell transcriptomics uncovers key immune drivers of vaccine efficacy in cattle

Summary Comprehensive characterization of bovine immune cell populations is essential for improving animal welfare and disease resilience. We performed single-cell RNA sequencing on over 29,000 peripheral blood mononuclear cells (PBMCs) from Angus cattle stratified by delayed-type hypersensitivity (...

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Main Authors: Annaleise Wilson, Pâmela A. Alexandre, Aaron M. Brice, Brad C. Hine, Aaron Ingham, Thibault P. R. A. Legrand, Caroline Royle, Dominic Niemeyer, Antonio Reverter, Stuart E. Denman, Ryan J. Farr
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Genomics
Subjects:
Adaptive immunity
Bovine immunology
Gamma-delta T cells
Innate immunity
Single cell sequencing
Transcriptome
Online Access:https://doi.org/10.1186/s12864-025-11915-0
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https://doi.org/10.1186/s12864-025-11915-0

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