Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines
Abstract A novel deep eutectic solvent (Thr/Mal-DES) was synthesized by mixing one mole of L-threonine (Thr) with one mole of malonic acid (Mal) and was characterized by FT-IR, 1H NMR, TGA/DTA, and densitometry techniques. Then, it was used as a highly effective catalyst for the rapid synthesis of c...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-08820-7 |
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| Summary: | Abstract A novel deep eutectic solvent (Thr/Mal-DES) was synthesized by mixing one mole of L-threonine (Thr) with one mole of malonic acid (Mal) and was characterized by FT-IR, 1H NMR, TGA/DTA, and densitometry techniques. Then, it was used as a highly effective catalyst for the rapid synthesis of chromeno[4,3-d]pyrimidines from the reaction of 4-hydroxy-coumarin, urea/thiourea and aldehyde under solvent-free conditions at 80 °C in high yields and short reaction times. |
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| ISSN: | 2045-2322 |