Exploring the mechanism of proteinuria reduction by hydroxychloroquine in IgA nephropathy using network pharmacology and molecular mocking

Exploring the mechanism of proteinuria reduction by hydroxychloroquine in IgA nephropathy using network pharmacology and molecular mocking

Abstract According to the 2021 KDIGO guidelines, hydroxychloroquine (HCQ) had been recommended for the treatment of IgA nephropathy (IgAN). However, the precise mechanisms by which HCQ ameliorated proteinuria in IgAN were not fully understood. This study investigated the potential mechanisms of HCQ...

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Bibliographic Details
Main Authors: Meiqi Lu, Yuxin Wang, Zheng Wan, Yixuan Chen, Mengshu Lin, Xiaoqi Deng, Xiaoxia Su, Qing Gao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Network pharmacology
IgA nephropathy
Hydroxychloroquine
miR-130b-3p
Online Access:https://doi.org/10.1038/s41598-025-97950-z
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https://doi.org/10.1038/s41598-025-97950-z

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