Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation

Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation

Sleep apnea is regarded as an important risk factor in the pathogenesis of Alzheimer disease (AD). Chronic intermittent hypoxia treatment (IHT) given during the sleep period of the circadian cycle in experimental animals is a well-established sleep apnea model. Here we report that transient IHT for...

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Bibliographic Details
Main Authors: Takeru Nagayama, Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Takashi Saito, Takaomi C. Saido, Shuji Wakatsuki, Toshiyuki Araki
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:Neuroscience Research
Subjects:
Sleep-disordered breathing
Sleep apnea
Chronic intermittent hypoxia
Alzheimer
Disease (AD)
β-Secretase 1 (BACE1)
Online Access:http://www.sciencedirect.com/science/article/pii/S0168010224000415
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