An Alternative Mechanistic Paradigm for the Electrochemical C‐Terminal Decarboxylation of Peptides

The C‐terminal decarboxylation of peptides provides an important opportunity to synthesize modern peptide pharmaceuticals that contain C‐terminal amides. This transformation can be achieved by electrochemical oxidation; however, the standard implementation depends on oxidation potential for selectiv...

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Bibliographic Details
Main Authors: Adam J. Sowers, Kevin D. Moeller, Kim S. Halskov
Format: Article
Language:English
Published: Wiley-VCH 2025-07-01
Series:ChemElectroChem
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Online Access:https://doi.org/10.1002/celc.202500142
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