Persistent type I interferon signaling within the brain of people with HIV on ART with cognitive impairment.

Persistent type I interferon signaling within the brain of people with HIV on ART with cognitive impairment.

To better understand the molecular mechanism that drives neuroinflammation, we analyzed the protein profiles of 27 brains from HIV with HIV (PWH) on antiretroviral therapy (ART), including various stages of HIV-associated neurocognitive disorders (HAND), and compared them to 9 HAND-negative controls...

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Main Authors: Yuyang Tang, Ling Xie, Ciniso Sylvester Shabangu, Dajiang Li, Gabriela da Silva Prates, Ashokkumar Manickam, Lilly M Wong, Antoine Chaillon, Edward P Browne, Sara Gianella, Wenzhe Ho, David M Margolis, Xian Chen, Wenhui Hu, Guochun Jiang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013411
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https://doi.org/10.1371/journal.ppat.1013411

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