FANTASIA leverages language models to decode the functional dark proteome across the animal tree of life

Abstract Protein functional annotation is crucial in biology, but many protein-coding genes remain uncharacterized, especially in non-model organisms. FANTASIA (Functional ANnoTAtion based on embedding space SImilArity) integrates protein language models for large-scale functional annotation. Applie...

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Bibliographic Details
Main Authors: Gemma I. Martínez-Redondo, Francisco M. Perez-Canales, Belén Carbonetto, José M. Fernández, Israel Barrios-Núñez, Marçal Vázquez-Valls, Ildefonso Cases, Ana M. Rojas, Rosa Fernández
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08651-2
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