NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism

NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism

Abstract Cuproptosis is a recently discovered form of regulated cell death triggered by mitochondrial copper accumulation and proteotoxic stress. Here, we provide the first evidence that glutathione (GSH), a major non-protein thiol in cells, acts as a cuproptosis inhibitor in pancreatic ductal adeno...

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Bibliographic Details
Main Authors: Jiao Liu, Hu Tang, Fangquan Chen, Changfeng Li, Yangchun Xie, Rui Kang, Daolin Tang
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Cuproptosis
Copper
Elesclomol
Glutathione
NFE2L2
SLC25A39
Online Access:https://doi.org/10.1038/s41598-024-81317-x
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https://doi.org/10.1038/s41598-024-81317-x

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