Shikonin inhibits epithelial-mesenchymal transition in glioblastoma cells by upregulating p53 and promoting miR-361-5p level to suppress ZEB1 expression

Shikonin inhibits epithelial-mesenchymal transition in glioblastoma cells by upregulating p53 and promoting miR-361-5p level to suppress ZEB1 expression

Abstract Objective Shikonin, an active compound from the rhizome of Lithospermum erythrorhizon, exerts anti-tumor effects in various cancers, including glioblastoma multiforme (GBM). This study explored the mechanism of Shikonin for inhibiting the migration and invasion of GBM cells, providing a rat...

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Bibliographic Details
Main Authors: Fengying Zhang, Zhiyi Liu, Yingbin Wang, Lin Zuo, Sicong Xu, Yin Liu, Hao Liang, Yixue Xue
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Neuroscience
Subjects:
Shikonin
GBM
miR-361-5p
Online Access:https://doi.org/10.1186/s12868-025-00956-6
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