Nephrocalcinosis tendency does not worsen under burosumab treatment for X-linked hypophosphatemic rickets: a multicenter pediatric study

Nephrocalcinosis tendency does not worsen under burosumab treatment for X-linked hypophosphatemic rickets: a multicenter pediatric study

BackgroundX-linked hypophosphatemic rickets (XLH) is associated with uninhibited FGF23 activity, which leads to phosphaturia, hypophosphatemia and depressed active vitamin D (1,25OH2D) levels. Conventional treatment with phosphate supplements and vitamin D analogs may lead to hypercalciuria (HC), ne...

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Main Authors: Shelly Levi, Daniel Landau, Miriam Davidovits, Mika Shapira Rootman, Avivit Brener, Shoshana Gal, Yael Borovitz, Ori Goldberg, Rachel Bello, Roxana Cleper, Yael Lebenthal, Yael Levy-Shraga, Dov Tiosano, Adi Chezana, Ravit Regev, Leonid Zeitlin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pediatrics
Subjects:
XLH
FGF23
burosumab
hypercalciuria
nephrocalcinosis
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2024.1487890/full
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https://www.frontiersin.org/articles/10.3389/fped.2024.1487890/full

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