DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1

DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1

Abstract RNA structure constitutes a new layer of gene regulatory mechanisms. RNA binding proteins can modulate RNA secondary structures, thus participating in post-transcriptional regulation. The DEAH-box helicase 36 (DHX36) is known to bind and unwind RNA G-quadruplex (rG4) structure but the trans...

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Main Authors: Yuwei Zhang, Jieyu Zhao, Xiaona Chen, Yulong Qiao, Jinjin Kang, Xiaofan Guo, Feng Yang, Kaixin Lyu, Yiliang Ding, Yu Zhao, Hao Sun, Chun-Kit Kwok, Huating Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54000-y
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https://doi.org/10.1038/s41467-024-54000-y

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