Induced Pluripotent Stem Cell-Derived Exosomes Promote Peripheral Nerve Regeneration in a Rat Sciatic Nerve Crush Injury Model: A Safety and Efficacy Study

Induced Pluripotent Stem Cell-Derived Exosomes Promote Peripheral Nerve Regeneration in a Rat Sciatic Nerve Crush Injury Model: A Safety and Efficacy Study

Peripheral nerve injury (PNI) remains a significant clinical challenge, often leading to long-term functional impairment. Despite advances in therapies, current repair strategies offer unsatisfactory clinical outcomes. Exosomes derived from induced pluripotent stem cells (iPSC-Exos) have emerged as...

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Bibliographic Details
Main Authors: Fatima Aldali, Yujie Yang, Chunchu Deng, Xiangling Li, Xiaojian Cao, Jia Xu, Yajie Li, Jianlin Ding, Hong Chen
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
induced pluripotent stem cell
exosome
safety
nerve regeneration
Schwann cells peripheral nerve injury
Online Access:https://www.mdpi.com/2073-4409/14/7/529
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