Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome

The decline in ovarian estrogen production is known to have detrimental health consequences and negatively affect the quality of life in menopausal women. Increasing estradiol levels is key to preventing disease in menopausal women. In this study, Lactobacillus gasseri CCFM1255 isolated from healthy...

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Main Authors: Qian Chen, Haiqin Chen, Jianxin Zhao, Wei Chen, Gang Wang
Format: Article
Language:English
Published: Tsinghua University Press 2024-11-01
Series:Food Science and Human Wellness
Subjects:
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2023.9250016
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author Qian Chen
Haiqin Chen
Jianxin Zhao
Wei Chen
Gang Wang
author_facet Qian Chen
Haiqin Chen
Jianxin Zhao
Wei Chen
Gang Wang
author_sort Qian Chen
collection DOAJ
description The decline in ovarian estrogen production is known to have detrimental health consequences and negatively affect the quality of life in menopausal women. Increasing estradiol levels is key to preventing disease in menopausal women. In this study, Lactobacillus gasseri CCFM1255 isolated from healthy infants was found to have a positive effect on estradiol production in ovariectomized rats. CYP19, the key enzyme catalysing the conversion of androgens into estrogens, was upregulated in adipose tissue upon CCFM1255 treatment. Untargeted metabolome analysis and targeted metabolite detection were used to identify the key metabolites altered by CCFM1255 treatment. CCFM1255 treatment significantly improved the serum concentration of glutamine (Gln). A significantly positive correlation was observed between serum Gln and estradiol concentrations. CCFM1255 treatment reshaped the structure of the gut microbiome, which was correlated with certain changes in serum metabolite concentrations. These results indicate that the provision of CCFM1255 as a dietary supplement may be an effective strategy to alleviate menopausal symptoms by increasing circulating estradiol.
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institution Kabale University
issn 2097-0765
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language English
publishDate 2024-11-01
publisher Tsinghua University Press
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series Food Science and Human Wellness
spelling doaj-art-27653cbdc7234d8db67f11da297d7b912025-01-10T06:57:02ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363301331010.26599/FSHW.2023.9250016Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolomeQian Chen0Haiqin Chen1Jianxin Zhao2Wei Chen3Gang Wang4State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaThe decline in ovarian estrogen production is known to have detrimental health consequences and negatively affect the quality of life in menopausal women. Increasing estradiol levels is key to preventing disease in menopausal women. In this study, Lactobacillus gasseri CCFM1255 isolated from healthy infants was found to have a positive effect on estradiol production in ovariectomized rats. CYP19, the key enzyme catalysing the conversion of androgens into estrogens, was upregulated in adipose tissue upon CCFM1255 treatment. Untargeted metabolome analysis and targeted metabolite detection were used to identify the key metabolites altered by CCFM1255 treatment. CCFM1255 treatment significantly improved the serum concentration of glutamine (Gln). A significantly positive correlation was observed between serum Gln and estradiol concentrations. CCFM1255 treatment reshaped the structure of the gut microbiome, which was correlated with certain changes in serum metabolite concentrations. These results indicate that the provision of CCFM1255 as a dietary supplement may be an effective strategy to alleviate menopausal symptoms by increasing circulating estradiol.https://www.sciopen.com/article/10.26599/FSHW.2023.9250016estradiolaromatasegut microbiotaamino acids
spellingShingle Qian Chen
Haiqin Chen
Jianxin Zhao
Wei Chen
Gang Wang
Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome
Food Science and Human Wellness
estradiol
aromatase
gut microbiota
amino acids
title Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome
title_full Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome
title_fullStr Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome
title_full_unstemmed Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome
title_short Lactobacillus gasseri CCFM1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome
title_sort lactobacillus gasseri ccfm1255 promotes peripheral estrogen synthesis in ovariectomized rats by modulating the gut microbiome and serum metabolome
topic estradiol
aromatase
gut microbiota
amino acids
url https://www.sciopen.com/article/10.26599/FSHW.2023.9250016
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AT haiqinchen lactobacillusgassericcfm1255promotesperipheralestrogensynthesisinovariectomizedratsbymodulatingthegutmicrobiomeandserummetabolome
AT jianxinzhao lactobacillusgassericcfm1255promotesperipheralestrogensynthesisinovariectomizedratsbymodulatingthegutmicrobiomeandserummetabolome
AT weichen lactobacillusgassericcfm1255promotesperipheralestrogensynthesisinovariectomizedratsbymodulatingthegutmicrobiomeandserummetabolome
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