Predicting the Effect of Meropenem Against <i>Klebsiella pneumoniae</i> Using Minimum Inhibitory Concentrations Determined at High Inocula

Predicting the Effect of Meropenem Against <i>Klebsiella pneumoniae</i> Using Minimum Inhibitory Concentrations Determined at High Inocula

<b>Background/Objectives:</b> Assessing antibiotic MICs at high bacterial counts is likely to disclose hidden bacterial resistance and the inoculum effect if present and therefore also reveal potential decreased antibiotic effectiveness. In the current study, we evaluated the predictive...

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Main Authors: Maria V. Golikova, Kamilla N. Alieva, Elena N. Strukova, Julia R. Savelieva, Daria A. Kondratieva, Svetlana A. Dovzhenko, Mikhail B. Kobrin, Vladimir A. Ageevets, Alisa A. Avdeeva, Stephen H. Zinner
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antibiotics
Subjects:
minimum inhibitory concentration at high bacterial inocula
antibiotic resistance
carbapenems
OXA-48 carbapenemase
KPC carbapenemase
meropenem
Online Access:https://www.mdpi.com/2079-6382/14/3/258
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https://www.mdpi.com/2079-6382/14/3/258

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