Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion
<b>Background</b>: Postoperative abdominal adhesion is a prevalent complication following abdominal surgery, with the incidence of adhesion reaching up to 90%, which may precipitate a range of adverse outcomes. Although fibrous membranes loaded with various anti-inflammatory or other dru...
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MDPI AG
2024-12-01
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| author | Junhan Li Hao Lin Jinghua Li Yi Wang |
| author_facet | Junhan Li Hao Lin Jinghua Li Yi Wang |
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| description | <b>Background</b>: Postoperative abdominal adhesion is a prevalent complication following abdominal surgery, with the incidence of adhesion reaching up to 90%, which may precipitate a range of adverse outcomes. Although fibrous membranes loaded with various anti-inflammatory or other drugs have been proposed for anti-adhesion, most of them suffer from drug-induced adverse effects. <b>Methods</b>: In this study, a lecithin-based electrospun polylactic acid (PLA) nanofibrous membrane (L/P-NM) was developed for the prevention of postoperative abdominal adhesion, utilizing the hydration lubrication theory. The loaded zwitterionic lecithin allows the nanofiber surface to strongly bind water molecules to create a hydration lubrication interface. <b>Results</b>: As the TGA results show, the content of bound water in the nanofibers increased significantly with the increase in the lecithin content. Tribological test results show that L/P-NM reached a minimum coefficient of friction (COF) of about 0.112. Additionally, the developed nanofibrous membranes possess favorable tensile property and biocompatibility. Rat postoperative abdominal adhesion model evaluation results demonstrated that L/P-NM possesses significant anti-adhesive performance, with an adhesion score of only 1. <b>Conclusions</b>: Therefore, this study offers a promising strategy for efficiently preventing abdominal adhesion. |
| format | Article |
| id | doaj-art-274d3352dba94b0991ef49d331e1d21d |
| institution | Kabale University |
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| language | English |
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| spelling | doaj-art-274d3352dba94b0991ef49d331e1d21d2024-12-27T14:46:30ZengMDPI AGPharmaceutics1999-49232024-12-011612156210.3390/pharmaceutics16121562Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal AdhesionJunhan Li0Hao Lin1Jinghua Li2Yi Wang3Basic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding 071000, ChinaCollege of Mechanical & Energy Engineering, Beijing University of Technology, Beijing 100124, ChinaBasic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding 071000, ChinaBasic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding 071000, China<b>Background</b>: Postoperative abdominal adhesion is a prevalent complication following abdominal surgery, with the incidence of adhesion reaching up to 90%, which may precipitate a range of adverse outcomes. Although fibrous membranes loaded with various anti-inflammatory or other drugs have been proposed for anti-adhesion, most of them suffer from drug-induced adverse effects. <b>Methods</b>: In this study, a lecithin-based electrospun polylactic acid (PLA) nanofibrous membrane (L/P-NM) was developed for the prevention of postoperative abdominal adhesion, utilizing the hydration lubrication theory. The loaded zwitterionic lecithin allows the nanofiber surface to strongly bind water molecules to create a hydration lubrication interface. <b>Results</b>: As the TGA results show, the content of bound water in the nanofibers increased significantly with the increase in the lecithin content. Tribological test results show that L/P-NM reached a minimum coefficient of friction (COF) of about 0.112. Additionally, the developed nanofibrous membranes possess favorable tensile property and biocompatibility. Rat postoperative abdominal adhesion model evaluation results demonstrated that L/P-NM possesses significant anti-adhesive performance, with an adhesion score of only 1. <b>Conclusions</b>: Therefore, this study offers a promising strategy for efficiently preventing abdominal adhesion.https://www.mdpi.com/1999-4923/16/12/1562electrospunnanofibershydration lubricationabdominal adhesion |
| spellingShingle | Junhan Li Hao Lin Jinghua Li Yi Wang Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion Pharmaceutics electrospun nanofibers hydration lubrication abdominal adhesion |
| title | Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion |
| title_full | Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion |
| title_fullStr | Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion |
| title_full_unstemmed | Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion |
| title_short | Engineered Lubricative Lecithin-Based Electrospun Nanofibers for the Prevention of Postoperative Abdominal Adhesion |
| title_sort | engineered lubricative lecithin based electrospun nanofibers for the prevention of postoperative abdominal adhesion |
| topic | electrospun nanofibers hydration lubrication abdominal adhesion |
| url | https://www.mdpi.com/1999-4923/16/12/1562 |
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