Genomic instability and CCNE1 amplification as emerging biomarkers for stratifying high-grade serous ovarian cancer

Genomic instability and CCNE1 amplification as emerging biomarkers for stratifying high-grade serous ovarian cancer

IntroductionOvarian cancer (OC) is one of the leading causes of cancer-related death in women worldwide. Treatment with PARP-inhibitors has significantly improved survival in patients with high-grade serous cancer (HGSC) bearing BRCA1/2 mutations (~22% of the cases), and/or homologous recombination...

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Main Authors: Elena Conca, Daniele Lorenzini, Emanuela Minna, Luca Agnelli, Matteo Duca, Marco Gentili, Beatrice Bodini, Maggie Polignano, Mara Mantiero, Silvia Damian, Andrea Devecchi, Gianpaolo Dagrada, Rita Carminati, Alice Ardore, Francesca Barbetta, Nathalia Brito Da Chuna, Andrea Guerrizio, Adele Busico, Iolanda Capone, Alberta Piccolo, Elena Tamborini, Federica Perrone, Massimo Milione, Biagio Paolini, Andrea Vingiani, Francesco Raspagliesi, Filippo De Braud, Giancarlo Pruneri
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
high-grade serous ovarian cancer (HGSC)
comprehensive genomic profiling (CGP)
homologous recombination deficiency (HRD) score
CCNE1 amplification
precision oncology cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1633410/full
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