A silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-d-glucopyranose functions as an efficient photosensitizer for photodynamic therapy

A silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-d-glucopyranose functions as an efficient photosensitizer for photodynamic therapy

We synthesized a new silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-d-glucopyranose (SGlc). Conjugation with SGlc improved A549 cellular uptake without significant changes in the photophysical and photochemical properties and subcellular localization. This improved cellular uptake led...

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Main Authors: Hiroaki Horiuchi, Kota Nishikawa, Nozomi Ishii, Koki Kano, Shunsuke Shinada, Nene Osawa, Aoi Horikoshi, Toshitada Yoshihara, Fumio Sugawara, Kengo Sakaguchi, Tetsuo Okustu, Shinji Katsura, Ichiro Matsuo, Masahiko Oshige
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Photodiagnosis and Photodynamic Therapy
Subjects:
Silyl porphyrin
Photodynamic therapy
Photosensitizer
6-deoxy-6-sulfo-α-D-glucopyranose
Online Access:http://www.sciencedirect.com/science/article/pii/S1572100023006257
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Summary:We synthesized a new silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-d-glucopyranose (SGlc). Conjugation with SGlc improved A549 cellular uptake without significant changes in the photophysical and photochemical properties and subcellular localization. This improved cellular uptake led to enhanced photodynamic activity. Furthermore, conjugation with SGlc suppressed dark toxicity. These advantages were not observed for a conjugate with a glucose molecule. These results indicated that the conjugation with SGlc is a promising strategy for enhancing photodynamic efficacy.
ISSN:1572-1000

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