A silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-d-glucopyranose functions as an efficient photosensitizer for photodynamic therapy

A silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-d-glucopyranose functions as an efficient photosensitizer for photodynamic therapy

We synthesized a new silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-d-glucopyranose (SGlc). Conjugation with SGlc improved A549 cellular uptake without significant changes in the photophysical and photochemical properties and subcellular localization. This improved cellular uptake led...

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Main Authors: Hiroaki Horiuchi, Kota Nishikawa, Nozomi Ishii, Koki Kano, Shunsuke Shinada, Nene Osawa, Aoi Horikoshi, Toshitada Yoshihara, Fumio Sugawara, Kengo Sakaguchi, Tetsuo Okustu, Shinji Katsura, Ichiro Matsuo, Masahiko Oshige
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Photodiagnosis and Photodynamic Therapy
Subjects:
Silyl porphyrin
Photodynamic therapy
Photosensitizer
6-deoxy-6-sulfo-α-D-glucopyranose
Online Access:http://www.sciencedirect.com/science/article/pii/S1572100023006257
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