HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance

HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance

Abstract Vinca alkaloids, a class of tubulin-binding agent, are widely used in treating cancer, yet the emerging resistance compromises their efficacy. Hepatoma up-regulated protein (HURP), a microtubule-associated protein displaying heightened expression across various cancer types, reduces cancer...

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Main Authors: Athira Saju, Po-Pang Chen, Tzu-Han Weng, Su-Yi Tsai, Akihiro Tanaka, Yu-Ting Tseng, Chih-Chia Chang, Chun-Hsiung Wang, Yuta Shimamoto, Kuo-Chiang Hsia
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53139-y
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https://doi.org/10.1038/s41467-024-53139-y

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