Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease

Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease

Abstract Background The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early pathological feature of Alzheimer’s disease (AD). BACE1 is the sole β-secretase for Aβ generation, making it an attractive therapeutic target for AD therapy. While BACE1 inhibitors have been shown to r...

Full description

Saved in:
Bibliographic Details
Main Authors: Akihiro Ishii, Joseph A. Pathoulas, Omar MoustafaFathy Omar, Yingying Ge, Annie Y. Yao, Tressa Pantalena, Neeraj Singh, John Zhou, Wanxia He, Patrick Murphy, Riqiang Yan, Xiangyou Hu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Neurodegeneration
Subjects:
BACE1
Amyloid plaques
Oligodendrocytes
ADAM10
IL33
Olig2
Online Access:https://doi.org/10.1186/s13024-024-00759-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13024-024-00759-z

Similar Items