Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer

Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer

While epithelial-mesenchymal plasticity (EMP) drives cancer metastasis, its regulation by redox dynamics remains poorly understood. Herein, we identified an oxidative stress-responsive CBP/SIRT1 axis that coordinated ZEB1 acetylation at K1108 to promote lung metastasis in triple-negative breast canc...

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Main Authors: Min Guo, Yan-Jing Wang, Jie Shi, Li-Xia Cao, Yang Ou, Xiao Jia, Chun-Chun Qi, Zhao-Xian Li, Yu-Xin Liu, Si-Yu Zuo, Qiu-Ying Shuai, Tian-Wen Yu, Hua-Yu Hu, Xiao Chen, Meng-Dan Feng, Yao Xue, Hang Wang, Pei-Qing Sun, Lei Liu, Yi Shi, Shuang Yang
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Redox Biology
Subjects:
Oxidative stress
ZEB1
Acetylation
Hybrid epithelial-mesenchymal phenotype
Lung metastasis
TNBC
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725003477
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