Expression and application of a novel Holin Hol6A3 in phage PD6A3 of Acinetobacter baumannii

Expression and application of a novel Holin Hol6A3 in phage PD6A3 of Acinetobacter baumannii

Abstract Background The current overuse of antibiotics presents significant challenges in treating drug-resistant bacterial infections. Bacteriophages have recently emerged as potential alternatives to antibiotics. Nevertheless, their high specificity and narrow host range limit their clinical appli...

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Bibliographic Details
Main Authors: Minle Wu, Yang Yang, Hanqing Wang, Beili Wang, Baishen Pan, Youhua Xie, Wei Guo
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Microbiology
Subjects:
Acinetobacter baumannii
Bacteriophages
Endolysin
Holin
ESKAPE
Online Access:https://doi.org/10.1186/s12866-025-04176-0
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