Prognostic Value of Deep Learning‐Extracted Tumor‐Infiltrating Lymphocytes in Esophageal Cancer: A Multicenter Retrospective Cohort Study

Prognostic Value of Deep Learning‐Extracted Tumor‐Infiltrating Lymphocytes in Esophageal Cancer: A Multicenter Retrospective Cohort Study

ABSTRACT Background Tumor‐infiltrating lymphocytes (TILs) have been proven to be important prognostic factors for various tumors. However, their prognostic significance within the context of esophageal squamous cell carcinoma (ESCC) remains inadequately explored. This study aims to assess the progno...

Full description

Saved in:

Bibliographic Details
Main Authors:	Peishen Li, Shujie Huang, Haijie Xu, Zijie Li, Sichao Wang, Zhen Gao, Yuejiao Dong, Zhuofeng Chen, Guibin Qiao, Hansheng Wu, Liangli Hong
Format:	Article
Language:	English
Published:	Wiley 2025-07-01
Series:	Cancer Medicine
Subjects:	deep learning esophageal squamous cell carcinoma prognostic factors tumor‐infiltrating lymphocytes
Online Access:	https://doi.org/10.1002/cam4.71054
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The size of CD8+ infiltrating T cells is a prognostic marker for esophageal squamous cell carcinoma
by: Kengo Shigehara, et al.
Published: (2025-07-01)

Tumor-infiltrating lymphocytes in colorectal carcinoma
by: Shovana Karki, et al.
Published: (2021-09-01)

A Study on Tumor-Infiltrating Lymphocytes in Different Subtypes of Breast Cancer
by: Polina Dimitrova, et al.
Published: (2021-06-01)

Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer
by: Wei Zhang, et al.
Published: (2025-05-01)

Clinical and Fundamental Research Progressions on Tumor-Infiltrating Lymphocytes Therapy in Cancer
by: Jiandong Hu, et al.
Published: (2025-05-01)

Intestinal and esophageal microbiota in esophageal cancer development and treatment
by: Yuta Baba, et al.
Published: (2025-12-01)

Clinical factors associated with growth and neoantigen reactivity of tumor infiltrating lymphocytes from metastatic epithelial cancers
by: Alexandra M. Gustafson, et al.
Published: (2025-06-01)

Intratumoral CD8+ tumor-infiltrating lymphocytes as prognostic predictors in radio-chemoradiotherapy-treated nasopharyngeal carcinoma
by: Xinjing Li, et al.
Published: (2025-05-01)

Breaking down physical barriers: strategies to improve lymphocyte infiltration for effective neoantigen-based therapies
by: Ting-Ting Chen, et al.
Published: (2025-06-01)

PSD3 as a context-dependent modulator of immune landscape and tumor aggressiveness in esophageal squamous cell carcinoma
by: Shujuan Luo, et al.
Published: (2025-08-01)

Spatial features of tumor-infiltrating lymphocytes in primary lesions of lung adenocarcinoma predict lymph node metastasis
by: Huibo Zhang, et al.
Published: (2025-07-01)

CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway
by: Liubing Hou, et al.
Published: (2025-08-01)

Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression
by: Devadarssen Murdamoothoo, et al.
Published: (2021-05-01)

Fixation of an esophageal stent using a novel re‐openable endoclip for a tracheoesophageal fistula
by: Yo Kubota, et al.
Published: (2024-04-01)

Tumor-infiltrating CD4+ CD25+ FOXP3+ Treg is associated with plasma EBV DNA and disease progression in nasopharyngeal carcinoma
by: Enzi Feng, et al.
Published: (2025-05-01)

Correlation of tumor budding with a novel and other established prognostic parameters in patients with invasive breast carcinoma
by: Neha D. Borde, et al.
Published: (2025-04-01)

Metabolic state uncovers prognosis insights of esophageal squamous cell carcinoma patients
by: Tingze Feng, et al.
Published: (2025-03-01)

Neoadjuvant chemoradiotherapy for thoracic esophageal squamous cell carcinoma: does everyone need it?
by: D. A. Chichevatov, et al.
Published: (2024-05-01)

A Propensity-Score Matched Analysis to Evaluate Local Treatment Modalities for Esophageal Squamous Cell Carcinoma in Over 80 years on A SEER Database
by: Li Q, et al.
Published: (2025-08-01)

Immunotherapy in advanced esophageal squamous cell cancer: earlier or later?
by: Shuang Wei, et al.
Published: (2025-07-01)

The pyroptosis-related gene signature predicts prognosis and reveals immune microenvironment infiltration in reclassified glioblastoma based on 2021 WHO classification
by: Xiaohong Zheng, et al.
Published: (2025-07-01)

Detecting radiation esophagitis using 18F-FAPI-04 PET/CT in patients with LA-ESCC treated with concurrent chemoradiotherapy
by: Xinying Hu, et al.
Published: (2025-05-01)

Effectiveness of chemotherapy with/without radiotherapy for stage IVb esophageal squamous cell carcinoma: a population-based target trial emulation study
by: Yao-Hung Kuo, et al.
Published: (2025-05-01)

The clinical pathological characteristics of malignant melanoma in nasal cavity and paranasal sinuses and its correlation with subsets of tumor infiltrating lymphocytes
by: WANG Lining, LIU Honggang
Published: (2025-04-01)

Meme Karsinomunda Tümörü infiltre eden T Lenfositlerin Yoğunluğunun Prognostik Faktörlerle İlişkisi
by: Mustafa Kösem, et al.
Published: (2025-06-01)

Identification of the important role of CA9 in immune infiltration and prognosis in cervical cancer
by: Zhi Zhao, et al.
Published: (2025-12-01)

Prognostic value of CD4<sup>+</sup> in patients with Т1–2N0M0 breast cancer
by: R. M. Paltuev, et al.
Published: (2023-08-01)

Sequential boost of intensity‐modulated radiotherapy with chemotherapy for inoperable esophageal squamous cell carcinoma: A prospective phase II study
by: Xing‐Wen Fan, et al.
Published: (2020-04-01)

Lymph Node Metastasis for pN+ Superficial Esophageal Squamous Cell Carcinoma
by: Yafan Yang, et al.
Published: (2025-01-01)

Integrative analysis of saliva-derived exosomal proteome and lipidome for the diagnosis of esophageal squamous cell carcinoma
by: Wei Zhong, et al.
Published: (2025-08-01)

A CT-based subregional radiomics nomogram for predicting local recurrence-free survival in esophageal squamous cell cancer patients treated by definitive chemoradiotherapy: a multicenter study
by: Jie Gong, et al.
Published: (2024-12-01)

Impact of first-line chemoimmunotherapy with or without radiotherapy on the prognosis of patients with locally advanced or metastatic esophageal squamous cell carcinoma: a multicenter, real-world, retrospective cohort study from China (NCT06478355)
by: Xinyi Liu, et al.
Published: (2025-07-01)

Anlotinib plus camrelizumab and chemotherapy as first-line treatment in patients with advanced esophageal squamous cell carcinoma
by: Mingfang Xu, et al.
Published: (2025-07-01)

Prognostic and predictive value of tumor infiltration proportion within lymph nodes in N1 colorectal cancer
by: Rujie Chen, et al.
Published: (2025-03-01)

Dual Targeting of Inflammatory and Immune Checkpoint Pathways to Overcome Radiotherapy Resistance in Esophageal Squamous Cell Carcinoma
by: Qu Z, et al.
Published: (2025-07-01)

Areca nut extract increased stromal tumor-infiltrating lymphocytes in 4-nitroquinoline-1-oxide-tumor-induced Sprague-Dawley rats [version 4; peer review: 1 approved, 2 approved with reservations]
by: Dina Keumala Sari, et al.
Published: (2025-06-01)

CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
by: Ji Cheng, et al.
Published: (2025-05-01)

Preoperative nutritional status and obesity are associated with muscle atrophy and fatty infiltration in degenerative rotator cuff tears
by: Li Cen, et al.
Published: (2025-08-01)

High oxidative phosphorylation represented by UQCRFS1 marks CD8 + tumor-infiltrating lymphocytes exhaustion in diffuse large B-cell lymphoma
by: Yiming Yang, et al.
Published: (2025-08-01)

Extranodal Manifestation of Chronic Lymphocytic Leukemia: A Case of Bilateral Breast Involvement
by: Ensiyeh Bahadoran, et al.
Published: (2025-06-01)