A genome-wide cross-trait analysis identifying shared genetic basis and causal relationships between Hunner-type interstitial cystitis and autoimmune diseases in East Asian populations

A genome-wide cross-trait analysis identifying shared genetic basis and causal relationships between Hunner-type interstitial cystitis and autoimmune diseases in East Asian populations

PurposeEpidemiological studies have demonstrated the clinical link between Hunner interstitial cystitis (HIC) and autoimmune diseases (ADs), suggesting potential shared genetic bases for their comorbidity. We aimed to investigate the shared genetic architecture and causal relationships between HIC a...

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Main Authors: Xinyi Lyu, Liao Peng, Xueyuan Xu, Yang Fan, Yong Yang, Jiawei Chen, Mengzhu Liu, Yuanzhuo Chen, Chi Zhang, Shiqin Yang, Sihong Shen, Jie Zhang, Xiao Zeng, Hong Shen, Deyi Luo, Yifei Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
cross-trait analysis
genetic epidemiology
Mendelian randomization
Hunner-type interstitial cystitis
autoimmune disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1417899/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1417899/full

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